The Wolf Part…..

We continue to mourn the untimely passing of our beloved compatriot DePat, known in real life as Susie Sampson, and also as author Patricia Holden.

Until we have a dedicated author for the Tuesday daily open thread, I will be posting “placeholders” like this one, which may or may not be spiced up with additional content.

Gudthots will take DePat’s old Thursday daily open thread.

Please notify me in advance if you would like to post anything in lieu of the Tuesday placeholder. We welcome all content – the topic doesn’t matter.

W

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Notes on Fenbendazole From Gail

Here is some information on “fenben” that Gail Combs has shared with me.

W

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The Gail Part…..

Fenbendazole

I want to start at the beginning with this paper from 2008.

Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins

Abstract

Diet containing the anthelminthic fenbendazole is used often to treat rodent pinworm infections because it is easy to use and has few reported adverse effects on research. However, during fenbendazole treatment at our institution, an established human lymphoma xenograft model in C.B-17/Icrprkdcscid/Crl (SCID) mice failed to grow. Further investigation revealed that the fenbendazole had been incorporated into a sterilizable diet supplemented with additional vitamins to compensate for loss during autoclaving, but the diet had not been autoclaved. To assess the role of fenbendazole and supplementary vitamins on tumor suppression, 20 vendor-supplied 4-wk-old SCID mice were assigned to 4 treatment groups: standard diet, diet plus fenbendazole, diet plus vitamins, and diet plus both vitamins and fenbendazole. Diet treatment was initiated 2 wk before subcutaneous flank implantation with 3 × 107 lymphoma cells. Tumor size was measured by caliper at 4-d intervals until the largest tumors reached a calculated volume of 1500 mm3. Neither diet supplemented with vitamins alone nor fenbendazole alone caused altered tumor growth as compared with that of controls. However, the group supplemented with both vitamins and fenbendazole exhibited significant inhibition of tumor growth. The mechanism for this synergy is unknown and deserves further investigation. Fenbendazole should be used with caution during tumor studies because it may interact with other treatments and confound research results.

Can’t have the Great Unwashed find a CHEAP effective cure for cancer now can we? ESPECIALLY when we have all that Turbo-Cancer on deck to be launched on the unsuspecting public. So in February of 2013 this paper trashing Fenbendazole as a cancer suppressant comes out.

Fenbendazole as a Potential Anticancer Drug

This is a CLASSIC example of how the Cabal ‘Proves’ a drug does not work. The first paper makes it clear that it is Fenbendazole PLUS DOUBLED VITAMINS, a synergistic effect, that targeted cancer and not Fenebendazole alone. So what do they do? they look at “…fenbendazole as a single agent and in combination regimens…[with] radiation or docetaxel…” NOT A VITAMIN IN SIGHT!

Conclusion

These studies provided no evidence that fenbendazole would have value in cancer therapy, but suggested that this general class of compounds merits further investigation.

This is such a simple but classic example of how the Cabal’s Psy Op works, that I could not resist documenting it.

The first paper is probably the paper Joe Tippen’s veterinarian friend read.

Man Claims Cheap Dog Deworming Medicine Cured His Terminal Cancer

…When small-cell cancer spreads as wide as it had in his case, the chances of survival are around one percent. Tippens thought he was going to die, and with nothing left to lose, he was willing to try anything in hopes of a miracle, even a dog dewormer called fenbendazole.

The desperate cancer sufferer stumbled upon the bizarre treatment while browsing a forum of his alma mater, Oklahoma State University. The post that caught his eye read “If you have cancer or know someone who does, give me a shout”. Joe had already signed up for an experimental treatment that doctors said wouldn’t save him but might extend his life expectancy from three months to a year, enough to at least meet his grandson. But he decided that contacting that forum poster couldn’t hurt either. To his surprise, that person was a veterinarian who had a very interesting story to tell…

So that is a bit of background. Now comes the part that puzzled me from our fellow QTreeper Linda.

Linda(@linda)

Reply to  PAVACA

November 27, 2024 11:04 #1373854

I think I’ve posted this before, but there is a major flaw with Joe Tippen’s protocol. He did a great job of getting people aware of fenbendazole, but his dosage is way too low for humans. 222 mg is the dosage you would give a 10 pound dog, not a human. Too many people are trying his protocol and finding it doesn’t work for that reason. A human needs 1,000-2,000 mg per day if you want results. I took 1500 mg per day for almost a year. You have to remember that Joe Tippens was on an immunotherapy trial at the same time he was taking fenben. It’s very likely the combo that cured his cancer….

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Linda(@linda)

Reply to  PAVACA

November 27, 2024 11:33 #1373879

Pavaca, thank you! What was stressed in my cancer group was to work your way up to the higher doses and monitor your liver numbers as you go. I started at 222 mg for a week, then 444 mg the next week, then kept increasing at that pace until I got up to 1500. I could have gone up to the 2000, but at that point I found out that my tumor had shrunk by half so I just stayed at that dose. I knew it was working and would continue to work at that point.

Fenben cancer

I took 1500 mg per day for almost a year.

500-1000 mg of either Tudca or milk thistle twice a day 1/2 hour before a meal to support your liver

high dose serrapeptase (120,000 spu twice a day) to get the dead cells out of your system after fenben kills them. Otherwise, your cancer will actually “eat” those dead cells as fuel. taken at least 2 hours after eating and at least 1/2 hour before eating.

Those 3 items plus ivermectin are critical.

However as someone who routinely worms horses, sheep and goats this puzzled me because the dosage was much higher than I routinely administer to my livestock.

HORSES:

The normal dose depends on the type of worm:

For the control of large strongyles, small strongyles, and pinworms the recommended dose is 5 mg fenbendazole per kg body weight (2.27 mg fenbendazole per pound) in a ONE (1) DAY treatment. For the control of ascarids the recommended dose is 10 mg fenbendazole per kg body weight (4.54 mg fenbendazole per pound) in a ONE (1) DAY treatment.

https://www.drugs.com/vet/horse-to-foal-2x.html

Fenbendazole | EquiMed – Horse Health Matters

….For foals and weanlings (less than 18 months of age) where ascarids are a common problem, the recommended dose is 4.6 mg/lb (10 mg/kg); one syringe will deworm a 550 lb horse. For control of encysted early third stage (hypobiotic), late third stage and fourth stage cyathostome larvae, and fourth stage larvae of Strongylus vulgaris, the recommended dose is 4.6 mg/lb (10 mg/kg) for 5 consecutive days; administer one syringe for each 550 lbs of body weight per day.

• Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship…

Side Effects

In horses, no side effects for a single dosage as high as 454 mg/lb were noted. Mutliple doses of 22.7 mg/lb were also administered on 15 consecutive days without side effects. In rare cases, antigens produced by the dying parasites may result in either a local or systemic hypersensitive reaction.

Precautions

Panacur® (fenbendazole) Paste 10% has been evaluated for safety in pregnant mares during all stages of gestation with doses as high as 11.4 mg/lb (25 mg/kg) and in stallions with doses as high as 11.4 mg/lb (25 mg/kg). No adverse effects on reproductivity were detected.

The recommended dose for control of fourth stage larvae of Strongylus vulgaris, 4.6 mg/lb (10 mg/kg) daily for 5 consecutive days, has not been evaluated for safety in stallions or pregnant mares…..

SHEEP:

The use is Extra-label in some countries but used anyway especially on lambs.
“The standard dosage of fenbendazole for sheep is typically 5 mg/kg of body weight.”

MULTIPLE SPECIES:

Med Ex Fenbendazole — Veterinary

Bolus-

• Sheep & goat: 1 bolus/animal (5 mg/kg body weight) as a single dose.
• Cattle & Horse: 7.5 mg/kg body weight as a single dose.
• Dog & Cat: 100 mg/Kg body weigh as a single dose.

Liquid-

• For use in drinking water.
• Poultry: 0.1 – 0.5 ml /kg body weight (20-100 mg/kg) as a single dose or 1 ml/200 kg body weight (1 mg/kg) daily for 5 days.
• Cattle: 1 ml/25 kg body weight as a single dose
• Horse: 1 ml/20-40 kg body weight as a single dose.
• Dogs: 1 ml/2 kg body weight as a single dose or 1 ml/10 kg body weight daily for 5 days. Or as directed by the Veterinary Physician.

RATS:

A Layman’s Guide to Health, Medication Use, Breeding, and Responsible Care of Pet Rats

Dosage Recommendations

10 mg/kg, PO, once, when treating for pinworms. 27
or
20 mg/kg, PO, q24hr for 5 days.  2, 41, 43, 44
or
20 mg/kg to 50 mg/kg, PO, q24hr for 5 consecutive days. *Note: higher dosing end for giardiasis only!*  27, 34, 41, 42, 44

>>>>>>>>>>>>>>>>>>>>>>>

And there it is, the solution to my puzzle.

The herbivores, horses, cattle, sheep and goats are 5 mg/kg to 7.5 mg/kg of body weight. The rat gets “10 mg/kg when treating for pinworms.“ And the carnivores, dog & cat: 100 mg/Kg body weight.

Dogs get ten times the dose for rats or livestock. So Tippens’ vet was recommending the livestock/rat dosage.

And a bit more on Fenbendazole. This is a long paper and I carved out some information I thought would be of interest.

FENBENDAZOLE

First Draft Prepared by

    Dr. William C. Keller,
    Food and Drug Administration,
    Rockville, Maryland USA

    1.  EXPLANATION

       
Fenbendazole is a light brownish-gray odourless, tasteless crystalline powder which is insoluble in water, but highly soluble in DMSO. It is a broad spectrum veterinary anthelmintic used in canines, equines, ruminants and swine. Fenbendazole has not been previously evaluated by the Joint FAO/WHO Expert Committee on Food Additives.

    2.  BIOLOGICAL DATA

    2.1  Biochemical aspects

    2.1.1  Absorption, distribution, and excretion

          Studies were performed to obtain basic information on the pharmacokinetics of 14C-fenbendazole after single oral doses in dogs, rats, rabbits, and sheep. The doses used were 5 mg/kg b.w. for sheep and 10 mg/kg b.w. for the other species. The material tested was administered as an aqueous suspension in 2% starch mucilage. All data are based on radioactivity, with metabolism not taken into account.

ABSORPSION
Absorption was slow, but more rapid in monogastrics. 
The highest concentrations measured in blood were: 
0.9 µg/ml in rats 5 to 7 hours post-administration, 
0.9 µg/ml in rabbits 8 hours post-administration, 
0.4 µg/ml in dogs 24 hours post-administration and 
0.32 µg/ml in sheep 2-3 days post-administration. 

Elimination from blood was 
6 hours in rats, 
13 hours in rabbits, 
15 hours in dogs, and
one day in sheep.

 In all animals except rabbits,elimination occurred >90% in faeces, with <7% in urine. In rabbits, excretion was 75% in faeces and 21% urine. 
At three days post-administration 
98% elimination in dogs, 
92% elimination in rabbits, and 
99% elimination in rats had occurred. 

Hepatic distribution at 7 days was highest (2.7 ppm) in sheep and lowest (0.06 ppm) in rats (Kellner & Christ, 1973)....