The colorized vintage image of vaccination for today’s header is courtesy of MedPage Today and Google Images.
Health Friday is a series devoted to Big Pharma, vaccines, general health, and associated topics. There are Important Notifications from our host, Wolf Moon; the Rules of our late, good Wheatie; and, certain caveats from Yours Truly, of which readers should be aware. They are linked here. Note: AI-generated items in today’s offering will be cited as such. If readers wish to post AI-generated items in today’s discussion thread, they must cite their source. Thank you.
The Moderna “combination modRNA influenza + modRNA COVID-19 vaccine”, mRNA-1083, also called mCOMBRIAX, has just been approved for use in Europe. mRNA-1083 (mCOMBRIAX) is a combination of the Moderna modRNA multi-strain influenza “vaccine”, mRNA-1010, plus the company’s “other” modRNA COVID-19 bioweapon “vaccine”, mRNA-1283 (mNEXSPIKE.) Yours Truly has written about the mRNA-1010 component of this “combo vaccine” here: https://www.theqtree.com/2026/02/27/health-friday-2-27-2026-open-thread-modernas-mrna-1010-and-the-end-run-around-hhs-sec-kennedy-jr-part-one/; and, here: https://www.theqtree.com/2026/03/06/health-friday-3-6-2026-open-thread-modernas-mrna-1010-and-the-end-run-around-hhs-sec-kennedy-jr-part-two/.
And now, on to the mRNA-1283 (mNEXSPIKE) component of mRNA-1083. Today’s offering is Part One of two:
Moderna’s “other” modRNA COVID-19 bioweapon “vaccine”, mRNA-1283 (mNEXSPIKE), was approved for use in the United States on 30 May 2025. The FDA Approval Letter to Moderna is here: https://www.fda.gov/media/186740/download. The Approval Letter for mNEXSPIKE was signed by David C. Kaslow, MD, Director of the Office of Vaccines Research and Review (a subdivision of FDA’s CBER department [Center for Biologics Evaluation and Research]). Dr. Kaslow is a Biden-era “holdover” at the FDA; he has been with CBER since 11 October 2022.
It appears that Dr. Kaslow relied solely on the “data” that was given to the FDA by Moderna regarding the “safety and efficacy” of mRNA-1283, prior to that agency’s granting approval of the BLA (Biologics License Application) that Moderna submitted for the product. In addition, it appears that Dr. Kaslow believed that the “data” that Moderna supplied to the FDA was sufficient enough to warrant a bypass of the review process by the VRBPAC group of the FDA (Vaccines and Related Biological Products Committee.) Please see the screenshot from Dr. Kaslow’s Approval Letter to Moderna for mRNA-1283 (mNEXSPIKE), below:
By the way, on 20 May 2025, Dr. Martin Makary (FDA Commissioner) and Dr. Vinay Prasad (Director of the FDA’s CBER division) published an “opinion piece” in the New England Journal of Medicine that purported to be their “opinions” regarding a “new approach” to COVID-19 “vaccination” in the United States. However, this was not really an “opinion piece” — it was implemented as FDA policy. This article by Dr. Prasad and Dr. Makary was published just 10 days before Dr. Kaslow sent the Approval Letter to Moderna for mRNA-1283 (mNEXSPIKE.) Did Dr. Prasad and Dr. Makary know in advance that Dr. Kaslow was going to issue this Approval Letter? Did HHS Secretary Kennedy, Jr., know? The “opinion piece” is here: https://doi.org/10.1056/NEJMsb2506929. “An Evidence-Based Approach to COVID-19 Vaccination.” Vinay Prasad, MD, MPH, and Martin Makary, MD, MPH. 20 May 2025. Below are two screenshots from this article: from the text; and, the Figure 2, which lists the “groups at severe risk from COVID-19.” The persons who would fall under one or more of the categories listed in Figure 2, even if these persons are under age 65, would “qualify” for “vaccination” with mNEXSPIKE:
The Package Insert for healthcare professionals for mRNA-1283 (mNEXSPIKE) is here: https://www.fda.gov/media/186738/download. Please see the screenshots of the following sections of this Package Insert, below: first, section 11 Description; then, section 12 Clinical Pharmacology, and section 13 Nonclinical Toxicology:
It would appear that Dr. Kaslow was comfortable in approving an injectable by Moderna (mRNA-1283, also called mNEXSPIKE) that contains the dangerous lipid nanoparticle SM-102; that contains at least PEG-related element (polyethylene glycol); and, that was not tested for carcinogenicity (the potential to cause cancer), for genotoxicity (the potential to damage genes, or to cause changes to genes, either of which can also cause cancer), or for impairment of male fertility.
It would also appear that Dr. Kaslow was comfortable with approving this modRNA COVID-19 bioweapon “vaccine” (mRNA-1283, also called mNEXSPIKE), which is purported to “prevent infection of COVID-19” — but, which claim has been proven to be wrong. From the FDA Package Insert for mNEXSPIKE:
The “prevent coronavirus disease 2019 (COVID-19)” statement is still being used by the FDA on COVID-19 bioweapon “vaccines” Package Inserts, despite the fact that Shrestha, et al., demonstrated in 2023 that “fully up-to-date vaccinated” Cleveland Clinic employees were more likely to become COVID-19 infected than those who were not “fully up-to-date” with COVID-19 “vaccination” (https://doi.org/10.1101/2023.06.09.23290893. “Risk of Coronavirus Disease (COVID-19) Among Those Up-to-Date and Not Up-to-Date on COVID-19 Vaccination.” Nabin K. Shrestha, et al. 13 June 2023.) Please the screenshot from this paper, below:
Why aren’t the Moderna “original” modRNA COVID-19 bioweapon “vaccine”, mRNA-1273 (SPIKEVAX), and the Moderna modRNA COVID-19 bioweapon “vaccine”, mRNA-1283 (mNEXSPIKE), the same? Please see the screenshot, below, from this article (https://www.drugs.com/medical-answers/what-difference-between-spikevax-mnexspike-3580787/, “What is the difference between SPIKEVAX and mNEXSPIKE?”, 2 September 2025:
However, regarding mNEXSPIKE, there apparently is a “blurred line” as to the use of it in persons under age 65 who do not have an “underlying medical condition.” Please see the screenshot below, from this article: https://health.mountsinai.org/blog/heres-what-you-need-to-know-about-the-new-covid-19-vaccines/, 23 September 2025; the advice is from Dr. Bernard Camins, MD, MSc, of Mount Sinai Hospital, in the “FAQ” section:
Note the language above, from Dr. Camins, regarding the ability of pharmacists to “prescribe vaccines off-label.”
Why is the N-terminal domain of the SARS-CoV-2 virus so important to Moderna that the company crafted a modRNA COVID-19 bioweapon “vaccine”, mNEXSPIKE, to utilize it? The N-terminal domain area is the “closest” (in terms of placement) to the receptor-binding domain (RCB) on the SARS-CoV-2 virus code. The N-terminal domain is also close to the S1/S2 cleavage site on the virus code. The receptor-binding domain is the part of the virus code that “makes sure” that the “payload” of the “vaccine” binds itself (enters into) the cells of the “vaccinated” person. These, in this writer’s opinion, make the N-terminal domain a “prime target” for the development of modRNA COVID-19 bioweapon “vaccines” that do not need to include the entire virus code, but still can “deliver the payload” through the receptor-binding domain mechanism. Please see: https://doi.org/10.3389/fcimb.2020.587269. “SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development.” Mei-Yue Wang, et al. 24 November 2020. Figure 1.) This is in contrast to the other modRNA COVID-19 bioweapon “vaccines” (by Moderna and by Pfizer-BioNTech) that contain the entire spike protein sequence (S1 and S2 areas.)
The issue regarding developing a modRNA COVID-19 bioweapon “vaccine” that only utilizes the N-terminal domain and the receptor-binding domain appears to have been determining exactly what “binding pocket” of the N-terminal domain would work. Scientists had been experimenting with the N-terminal domain to find such a “binding pocket”: for example, as described in this paper, from 2022: https://doi.org/10.1016/j.csbj.2022.11.004. “Structural and energetic analyses of SARS-CoV-2 N-terminal domain characterise sugar binding pockets and suggest putative impacts of variants on COVID-19 transmission.” Jonathan Lees, et al. 17 November 2022. Please see the screenshots from this paper, below; first, the Abstract; followed by the Graphical Abstract:
It appears that Moderna did find such an N-terminal “binding pocket” to use for the development of mNEXSPIKE. And, it appears that the company’s decision to “harness” the mechanism to the S1 area of the SARS-CoV-2 spike protein, as opposed to using the entire S1/S2 sequence, is due to the fact that the S1 area is that which appears to be the most “effective” in regards to the Delta and Omicron variants of the virus. Please refer to: https://pubmed.ncbi.nlm.nih.gov/38034565. “SARS-CoV-2 spike protein S1 subunit induces potent neutralizing responses in mice and is effective against Delta and Omicron variants.” Tarlan Mamedov, et al. 14 November 2023. Please see the screenshot, below, of the Conclusion from this paper:
Note that Mamedov, et al., used a tobacco plant to produce the S1 protein from SARS-CoV-2, which they then tested against Delta and Omicron virus variants.
In this writer’s opinion, mRNA-1283 (mNEXSPIKE) cannot be thought of as “mRNA-1273 (SPIKEVAX) Lite.” mNEXSPIKE contains the S1 spike protein of an Omicron variant of SARS-CoV-2. mNEXSPIKE contains the dangerous lipid nanoparticle, SM-102, that mRNA-1273 (SPIKEVAX) also contains. mNEXSPIKE contains N1-Methylpseudouridine (which will destroy the RNA of the “vaccinated” body’s natural Uridine, replacing it with a lab-created chemical compound that has no natural, beneficial mechanism for the body), which mRNA-1273 (SPIKEVAX) also contains. In this writer’s opinion, the only difference between mRNA-1273 (SPIKEVAX) and mNEXSPIKE is that the latter “vaccine” does not contain the S2 area of the spike protein.
To be continued in Part Two.
THERE IS NO PLACE IN THE HUMAN BODY FOR AN mRNA, A modRNA, AN saRNA, OR A taRNA PRODUCT OF ANY KIND, IN ANY FORM. THERE MUST, FIRST, BE MUCH MORE RESEARCH INTO THESE GENE-ALTERING THERAPY PLATFORMS AND PRODUCTS. THERE MUST, SECOND, BE IRREFUTABLE PROOF THAT THESE GENE-ALTERING THERAPY PLATFORMS AND PRODUCTS ARE TRULY “SAFE AND EFFECTIVE.”
Peace, Good Energy, Respect: PAVACA
(Intellectual Disclaimer and Notice: Other than URLs and related items available on the Internet, the ideas and opinions of today’s offering are by PAVACA. Credit must be given to PAVACA if the ideas and opinions of today’s offering are used by other blog writers, by podcasters, or in social or print media.)
We know the COVID jabs are not “safe and effective.” We’ve seen that they’re not safe, and I thought it had been shown that they’re not effective either. I can’t imagine these new ones being any different, especially with the reliance on the drug-maker’s assertions vs. rigorous outside testing.
You are here.
Some time ago, I met someone at a Barnes & Noble near my home. We got into a discussion of how difficult it was to keep a vehicle operating within California’s insane repair laws….and other things….and it turns out she has an interesting career.
She does travel to things like eclipses.
https://www.betchartexpeditions.com/
You can say that cthulhu sent you, though it might not help.
Exactly right.
https://xcancel.com/ConceptualJames/status/2031756395599532054
https://twiller.com/ConceptualJames/status/2031756395599532054
@ConceptualJames
Mar 11
Addressing Zoomerslop.
A real Gen Z quote:
“Of all my friends, Israel is the very first thing that they want to learn about and understand, because it does go back to America First. I, in fact, have not talked to one Gen Z conservative that has been pro-Israel. Everybody I’ve talked to is questioning Israel.”
Listen, kids. Doesn’t that seem really f–king weird to you? The main thing your whole cohort cares about is another country, one that is allied with us and kicking ass in the most Top Gun way you can imagine? Doesn’t it seem weird that everyone in your generation is focused on another country that isn’t even attacking us?
It should seem weird because it is weird. The reason it’s happening is not because Israel is relevant to all of your lives. The reason it is happening is because you’re being propagandized.
Let me repeat the quote in words that hit your big brothers and sisters right in the assholes ten years ago:
“Of all my friends, privilege is the very first thing that they want to learn about and understand, because it does go back to Social Justice. I, in fact, have not talked to one Millennial liberal that doesn’t question our privilege. Everybody I’ve talked to is questioning privilege: white privilege, male privilege, straight privilege.”
Do you think that was normal? No, it wasn’t normal either. Every Gen X or older person can tell you that the young people in their generations had many, varied, and diverse interests. There was no top of mind for everyone in a generation. But the Millennials got it with privilege and Social Justice, and you’re getting it with Israel and “America First.”
Kids, listen to me.
This is not normal.
This is not natural.
This is the result of dedicated propaganda campaigns.
You are being propagandized.
The method of propaganda being used is primarily something called “reflexivity,” which is a method developed by George Soros to create mass movements of belief around deliberate lies that he called “fertile fallacies.”
He called them “fertile fallacies” because they are lies (fallacies, errors, differences between what’s believed and what’s really true) that can take off (fertile) in a population. They’re “lies with legs,” it has been said.
The method of “reflexivity” is to get everyone believing the same erroneous stuff in an increasing way at the same time. This is accomplished through local media saturation: everyone is talking about the same thing in the same way at the same time, and eventually so are your friends. Then the ideas “reflect” all around you creating a sense of social consensus and widespread belief.
Reflexive campaigns are everywhere now. On the Left, we call them the “Current Thing.” We have rafts of memes of the NPCs all changing their tune or saying the same thing or being reprogrammed or being hypnotized into the newest Current Thing, which changes when the media does.
That’s you! Now! You’re being Sorosed!
The reason everyone in your generation is suddenly talking about Israel is because propagandists in your midst have made Israel your “current thing.” It is a reflexive campaign, and you aren’t just a victim but are playing your part.
The framing for that reflexive campaign is “America First.” The propagandists are exploiting your love of country and frustration with bad actors in our governments and their “global partners,” which are increasingly being exposed, to get you attached to a bunch of fertile fallacies about Israel, all of which play upon your fears, anxieties, frustrations, and love for your beautiful country.
Here are some:
“Israel is not really our greatest ally. It isn’t even an ally.”
“We can’t afford things at home because Israel gets aid money.”
“This is Israel’s War, and I’m not dying in Israel’s War.”
“Israel attacked the USS Liberty and isn’t our friend.”
“Jeffrey Epstein was working with Israel.”
“Israel is too weak to exist on its own so it manipulates America into supporting it.”
“Israel is a settler-colonialist project that is doing a genocide of the indigenous Palestinians.” (OOPS MY BAD THAT’S THE ONE THEY’RE TELLING YOUR FRIENDS ON THE LEFT)
“Israel is a warmongering vassal state under with US protectorate status that is seeking to become a regional power by starting random wars that it drags the US into and doing genocide.” (AHH THAT’S YOUR VERSION OF THE SAME LIE!)
None of these (or dozens more) is accurate. They are all fallacies (lies) designed to take off in the social and emotional environments you find yourselves in, driven by media and political propagandists who have their own agendas but need your help (just like the NPCs on the Left).
The reason you are so obsessed (and, yes, that’s obsession) with Israel is because you are being targeted by reflexive propaganda campaigns designed to make you all fixate on this object that can be alleged to cause most of your problems. In fact, it causes few, if any, of your problems and is actively solving many problems you are blessed enough not to even know that you have.
Friends, you are being propagandized. You are being led to focus and fixate on these things because it serves dark interests that are not your own.
The same Soros techniques that work on the Left are being used on you, and you’re helping them work.
How do you stop them?
1) Stop listening to propagandists. This is actually really important.
2) Seek out the opposite side of what you’re being told and try to understand the truth.
3) Use critical thinking.
4) Ask yourself if you’re being asked to think about issues or asked to feel about issues.
5) Be skeptical of something that appears suddenly in the news or on platforms that everyone is repeating all the time all at once. That’s how Soros’s reflexivity works.
6) Understand, just like how it was true with CNN and other trusted news sources, that trusted sources can be bought, at which point they are not trustworthy anymore and are using your trust to manipulate you.
The biggest anti-America operation that’s happening right now is the sudden skeptical-to-hostile fixation on Israel. Notice that it’s only been a thing since October 7, 2023, exactly the same time the parallel propaganda wave began on the Left. What you’re participating in is the side of that same campaign tailored to your values, your anxieties, and your frustrations. No different.
This campaign is rapidly turning people against not just Israel and often Jews (against your values, I’m sure), but against MAGA, Trump, the United States and its role in the world, and the Republican Party. Who benefits from that? Not you. Not us.
Isn’t it weird to you that so many people suddenly believe exactly the opposite of what they believed in 2022? Isn’t it weird to you that everyone considers this such a big issue?
It should be weird because it is. That’s the signature of a propaganda campaign, and you are its primary targets.
Mar 11, 2026 · 3:37 PM UTC