Dear KAG: 20200401 Open Thread

And FAUCI wants a FULL CLINICAL TRIAL:
(I could not find the FDA guidelines quickly so this will do:
What Happens in a Clinical Trial?

What happens in phase 0?
Phase 0 of a clinical trial is done with a very small number of people, usually fewer than 15. Investigators use a very small dose of medication to make sure it isn’t harmful to humans before they start using it in higher doses for later phases…

DONE since it is an old drug

What happens in phase I?
During phase I of a clinical trial, investigators spend several months looking at the effects of the medication on about 20 to 80 people who have no underlying health conditions.

DONE since it is an old drug

What happens in phase II?
Phase II of a clinical trial involves several hundred participants who are living with the condition that the new medication is meant to treat. They’re usually given the same dose that was found to be safe in the previous phase.
Investigators monitor participants for several months or years to see how effective the medication is and to gather more information about any side effects it might cause.….

DONE since it is an old drug.

What happens in phase III?
Phase III of a clinical trial usually involves up to 3,000 participants who have the condition that the new medication is meant to treat. Trials in this phase can last for several years.
The purpose of phase III is to evaluate how the new medication works in comparison to existing medications [or procedures like ventilation? – GC] for the same condition. To move forward with the trial, investigators need to demonstrate that the medication is at least as safe and effective as existing treatment options.
To do this, investigators use a process called randomization. This involves randomly choosing some participants to receive the new medication and others to receive an existing medication.
Phase III trials are usually double-blind, which means that neither the participant nor the investigator knows which medication the participant is taking. This helps to eliminate bias when interpreting results.
The FDA usually requires a phase III clinical trial before approving a new medication. Due to the larger number of participants and longer duration or phase III, rare and long-term side effects are more likely to show up during this phase.
If investigators demonstrate that the medication is at least as safe and effective as others already on the market, the FDA will usually approve the medication.

⬆️⬆️⬆️THIS IS WHAT FAUCI WANTS!⬆️⬆️⬆️
Since there are two drugs (three if you count zinc) I am sure he wants a FULL FACTORIAL DESIGNED EXPERIMENT.
A Full Factorial Design Example
“Note that the factor settings have been coded, replacing the low setting” [No Drug] “ by -1 and the high setting” [Drug] “by 1.”
Let X1 = Hydroxychloroquine
Let X2 = Azithromycin
Let X3 = Zinc
Not that this is a SIMPLE trial. It does not look at dosage levels or Chloroquine instead of Hydroxychloroquine.
TABLE 3.6 A 2^3 Two-level, Full Factorial Design Table Showing Runs in `Standard Order’
…….X1 .. X2 .. X3
1 … -1 … -1 … -1
2 … +1 …-1 … -1
3 … -1 … +1 …-1
4 … +1 …+1 …-1
5 … -1 … -1 … +1
6 … +1 …-1 … +1
7 … -1 … +1 …+1
8 … +1 …+1 …+1
LONG STORY SHORT: Only ONE out of EIGHT people would get the full medical treatment. If Hydroxychloroquine alone sort of works but more slowly, TWO out of eight get a better chance to live. This means SIX OUT OF EIGHT are LEFT TO HEAL ON THEIR OWN using current medical practices!
If the study of 3,000 people then 6 out of 8 or 75% or 2250 do not get treated with the new Trump Protocol.
Interesting how Vaccines get up and running SO MUCH FASTER….

HMMMMMmmmmm I do not see any blondes or redheads in those photos. They all look like they have BLACK HAIR… Chinese, Iranian, M13…