Joe Biden didn’t win. This is our Real President:
AND our beautiful REALFLOTUS.
This Stormwatch Monday Open Thread remains open – VERY OPEN – a place for everybody to post whatever they feel they would like to tell the White Hats, and the rest of the MAGA/KAG/KMAG world (with KMAG being a bit of both).
And yes, it’s Monday…again.
But we WILL get through it!
We will always remember Wheatie,
Pray for Trump,
Yet have fun,
and HOLD ON when things get crazy!
We will follow the RULES of civility that Wheatie left for us:
Wheatie’s Rules:
- No food fights.
- No running with scissors.
- If you bring snacks, bring enough for everyone.
And while we engage in vigorous free speech, we will remember Wheatie’s advice on civility, non-violence, and site unity:
“We’re on the same side here so let’s not engage in friendly fire.”
“Let’s not give the odious Internet Censors a reason to shut down this precious haven that Wolf has created for us.”
If this site gets shut down, please remember various ways to get back in touch with the rest of the gang:
- Our backup site, The Q Tree 579486807, https://theqtree579486807.wordpress.com/
- Our old alternative site, The U Tree, where civility is not a requirement
- Our Gab Group, which is located at https://gab.com/groups/4178
- Our various sister sites, listed in the Blogroll in the sidebar
Our beloved country is under Occupation by hostile forces.
Daily outrage and epic phuckery abound.
We can give in to despair…or we can be defiant and fight back in any way that we can.
Joe Biden didn’t win.
And we will keep saying Joe Biden didn’t win until we get His Fraudulency out of our White House.
Word of The Week:
G-quadruplex
and related terms such as
G4 knot and G-tetrad
nouns
In molecular biology, G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine.[2] They are helical in shape and contain guanine tetrads that can form from one,[3] two[4] or four strands.[5] The unimolecular forms often occur naturally near the ends of the chromosomes, better known as the telomeric regions, and in transcriptional regulatory regions of multiple genes, both in microbes[6][7] and across vertebrates [8][7] including oncogenes in humans.[9] Four guanine bases can associate through Hoogsteen hydrogen bonding to form a square planar structure called a guanine tetrad (G-tetrad or G-quartet), and two or more guanine tetrads (from G-tracts, continuous runs of guanine) can stack on top of each other to form a G-quadruplex.
The placement and bonding to form G-quadruplexes is not random and serve very unusual functional purposes. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central channel between each pair of tetrads.[3] They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular, or tetramolecular.[10] Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel. G-quadruplex structures can be computationally predicted from DNA or RNA sequence motifs,[11][12] but their actual structures can be quite varied within and between the motifs, which can number over 100,000 per genome. Their activities in basic genetic processes are an active area of research in telomere, gene regulation, and functional genomics research.[13][14]
LINK: https://en.wikipedia.org/wiki/G-quadruplex
Shown in a picture
Wolf’s easy description
Those genetic bases (the little flat molecules with one or two rings and lots of “N” and “O” in them) can not only bond to each other in PAIRS between different bases – the base guanine (G) can bond to itself if it makes a circle big enough for FOUR of them instead of just a pair (see left picture above). Sometimes a metal ion in the center can help this happen.
This competing form of binding disrupts the nice, neat, normal “double helix” binding, but not permanently.
When G4 binding happens, there are many working ways that the little squares can form. These squares tend to STACK just like in normal DNA, and so sequences that are rich in guanine can build these stacks easily, if the guanines are in the right places. Alternatively, two or more strands of DNA or RNA can join in these knots, but at a minimum, a single strand can do it, as shown on the right of the graphic above, where the sequence knots up against itself.
Note that this is more like “knots in velcro”, and not like various circling knots we are familiar with.
Used in a sentence
“For over two decades, the prime objective of the chemical biology community studying G-quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to obtain mechanistic interpretations.”
LINK: https://www.sciencedirect.com/science/article/pii/S2451945621000416
Why it’s important for COVID vaccines
The COVID vaccine mRNA is not natural – and not only in that normal bases are substituted with modified bases. It also has been “codon optimized”, meaning the very sequence of bases was changed from the viral sequence, by substituting base triplets with synonymous ones, that are known to process faster in humans. But the problem is that these changes are rich in guanine, making the knotting more likely. This not-fully-equivalent substitution has potential pharmacological consequences. In a sense, viral evolutionary intelligence was ignored (a beautiful point made by Kevin McKernan).
Music
Let’s start off with some LIVE DRINKABY
Sadly, DRINKABY line dancing hasn’t just infected the other side of the Pacific – it has become a destructive influence in Spongebob’s hometown of Bikini Bottom.
This led to me watching (please skip, unless you desire to prove the full effect that follows) a video compilation of the times the town of Bikini Bottom was destroyed in the cartoon “Spongebob Squarepants”.
When that destructive propaganda of mayhem was over (yes, even Spongebob is one of their tentacles), I needed the following.
This is only 18 minutes – and worth every one of them.
But here is the one you need right now!
You know, maybe we’ll just leave it right there and skip the usual worldly “stuff”!
Although I did promise PAVACA that I would explain something, so we’ll try that.
MOAR DNA and RNA STUFF
Check out this video, which shows TRANSCRIPTION – the normal, natural way that DNA is turned into RNA in living organisms on this planet.
What you are seeing here is “good”!
NEXT – Somebody else posted this under their own timeline on X.
Transcription is the process by which the information in DNA is copied into messenger nRNA (mRNA) for protein production.
— Massimo (@Rainmaker1973) December 16, 2023
This is a visualization of how it takes place.
[dnalearningcenter]https://t.co/TcysUSm2qx
NOW – the molecular biologist who found the DNA contamination problem in the mRNA vaccines – Kevin McKernan – reposted the latter video with a comment about something which is NOT in the video, but which would change it. Here is his comment.
Let me explain what Kevin is saying.
Kevin is not commenting about the transcription process shown here. He is NOT talking about the red DNA strand, either. He is commenting about the yellow strand of mRNA which is being produced.
“Now add N1 methyl Pseudouridine and watch that yellow strand turn into quadruplex G knot.”
He is saying that if you change the uridines in that molecule to N1-methyl-pseudouridine, as was done in the Pfizer vaccine, the yellow strand of mRNA will “kink up” with G-quadruplex knots.
He explains that further, when somebody wrongly claims the video is showing translation (creation of proteins) and not transcription (creation of mRNA). Observe.
So to sum up, he is saying that the “good” “yellow” mRNA produced in the video was corrupted by the modifications that were made to it by Pfizer.
He says the following things:
- it’s transcription, not translation, that is being shown
- the “pseudo-uridine” changes done to the viral mRNA sequence make the mod-RNA dissociate more easily
- the same changes make the mod-RNA form G4-quadruplexes easier
- Pfizer also changed the code to include more guanines (G), which means more quadruplexes
- all the G4-based KNOTS that are present in the mod-RNA cause the subsequent TRANSLATION step (looks similar to the video, but it’s PROTEIN being formed) to suddenly PAUSE, just like a KNOT in a climbing rope will lock up against a device until it is untangled. This is the “ribosomal pausing” he’s talking about.
So how does the DeMarinis paper figure into this?
The DeMarinis paper showed that the Pfizer vaccine can be reverse-transcribed from mod-RNA back into DNA by human liver cells. Reverse transcription would look pretty much like the video of transcription, except that RNA would be read, and DNA would spit out.
Whether that DNA is incorporated into the genome or not is unknown, but it is a huge concern, because another group (Jaenisch paper) showed that the COVID virus SARS-CoV-2 can and does incorporate its spike into the genome of some patients, AND yet another group (Mehedi paper) showed that the viral spike shepherds its own mRNA into the nucleus of human cells, where reverse transcription could happen.
I wanted people to see a bigger point – that this repeated and coincidentally connected “bungling” by Pfizer and its allies, which weirdly matches WEF’s dream of “hacking humanity”, is worthy of a bit of suspicion.
When a trail of disconnected yet matching footprints goes in some direction, it’s rather logical that somebody was purposefully passing that way.
It sure looks to me like the various “negligent” yet clearly convenient aspects of this whole exercise, add up to an attempt to gain a population-wide hack into the human cell nucleus.
Just sayin’!
That’s all for now.
Until victory, have faith!
And trust the big plan, too!
And as always….
ENJOY THE SHOW
W
