Health Friday 11.8.2024 Open Thread: The Insidious N1-Methylpseudouridine in the modRNA COVID-19 “Vaccines”

The above free vintage image of DNA/RNA and lab equipment is courtesy of Google Images.

Health Friday is a series that discusses Big Pharma, vaccines, general health, and associated topics. Today’s post goes down several “rabbit holes”; Yours Truly believes they are all relevant to the core observation of the piece. There are multiple screenshots, and also a General Summary at the end. The discussion today is not limited to what is presented here: It is an Open Thread. As the post involves items related to the COVID-19 modRNA “vaccines”, it is dedicated to the memory of Yours Truly’s “fully vaccinated and boosted” brother Sam, who passed away last week due to complications from, among other things, “sudden-onset dementia”; and, to the memory of her cousin Bill, who “died suddenly and unexpectedly” in September 2023. May they rest in eternal Peace.

There are Important Wolf Moon Notifications, the Rules of our late, good Wheatie, and caveat items from Yours Truly, of which readers should be aware. These are all linked here.

Today’s post is about one of the ingredients of the modRNA COVID-19 “vaccines”: a lab-synthesized version N1-Methylpseudouridine.

To begin: Once upon a time, a very long time ago (say, about 2.7 billion years ago), an organism domain evolved into being on the Earth. The name of this organism is Archaea. It is a “middle-position” domain between the domains of Eukaryotes and of Bacteria. Archaea gradually evolved into multiple types of Phyla (a position between Kingdom and Class in taxonomic rank.) Archaea are a large part of what is called microbiota (a “range” of microorganisms that include Archaea, bacteria, fungi, and viruses.) Archaea are literally “all over the place”, including in the human gut microbiome, the plankton in the waters of the Earth, and in the Earth’s soil. Archaea can “communicate” with each other through a kind of “cross-talk.” The various types of this microorganism can exist in all kinds of places and in conditions of extreme heat or extreme cold. Archaea are a kind of “recycling center” for carbon, nitrogen, and sulfur, depending on where it lives. Methanogen Archaea “…play an important role in the decay of organic matter…”, such as would be seen in a swamp. (Remember this for later in the post.) https://en.wikipedia.org/wiki/Archaea. Below is an image of some types of Archaea:

More information about Archaea and what it does is here: https://pmc.ncbi.nlm.nih.gov/articles/PMC1578729/, “The origin and evolution of Archaea: a state of the art”, by Simonetta Gribaldo and Celine Bochier-Armanet, 9 May 2006. A portion of the Introduction of this paper is below:

Again, remember the reference to methanogensis related to Archaea for further down in today’s post.

Then, there is Uridine.

Uridine is an RNA component that is manufactured by the Liver in the human body. It is either synthesized from foods that contain Uridine in the RNA of the food; or, if the body is not taking in sufficient food sources, Uridine production shifts to the adipose tissues (fat tissues) of the body. The importance of Uridine presence in the human body cannot be over-emphasized. Uridine crosses the Blood-Brain Barrier and helps to regulate mood, dopamine release, and other functions of the brain; It can help to mitigate Alzheimer’s Disease; it helps to regulate body temperature and circadian rhythm; it helps in tumor decrease; it has profound positive effects on the Central Nervous System; and more: https://pmc.ncbi.nlm.nih.gov/articles/PMC10937367/, “Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases”, Yueyuan Yang, et al., 28 February 2024. Food sources of Uridine include beer; Brewer’s Yeast; beets; tomatoes; goat’s milk and cheese; organ meats (liver, etc.); fish; molasses; and, walnuts: https://en.wikipedia.org/wiki/Uridine; and, https://pubmed.ncbi.nlm.nih.gov/21401985/, “Uridine function in the central nervous system”, Juliana Kardos, et al., 2011. Below is the Abstract from the Kardos, et al., paper:

More on what Uridine does to help the brain: https://doi.org/10.1007/s40120-020-00227-y, “Potential Neurogenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment”, Barry S. Samuel, et al., December 2020; https://coverthree.com/blogs/brain-health/uridine, “Uridine: The Elixir of Cognitive Enhancement”; https://doi.org/10.1146/annurev-nutr-080508-141059, “Use of Phosphate Precursors to Promote Synaptogenesis”, Mehmet Cansev, et al., May 2009; www.theqtree.com/2024/10/18/health-friday-10-18-2024-special-edition-neurological-effects-of-the-covid-19-vaccines-physical-and-psychological/; and, www.sciencedirect.com/topics/biochemistry-genetics-and-molecule-biology/uridine (a list of various topics on Uridine); via the “Uridine” topic on the list just referenced, a screenshot below from the book, Nutritional and Herbal Therapies for Children and Adolescents, by George M. Kapalka (2010):

Here is an image of the chemical construction Uridine, per https://en.wikipedia.org.wiki/Uridine:

And now, to Pseudouridine:

Natural Pseudouridine (as opposed to the lab-created versions) appears in the RNA of the human body. It is a “by-product” of RNA mechanisms in the body. It is also found in yeast and in E. coli (https://en.wikipedia.org/wiki/Pseudouridine.) If one or more of the mechanisms involved in the creation of Pseudouridine become “aberrant”, this can contribute to the onset of cancer or to certain types of genetic disorders (www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(22)00058-X. “Decoding pseudouridine: an emerging target for therapeutic development”, Jonas Cerneckis, et al., June 2022. The Abstract of the Cerneckis, et al., paper, is below:

Below is an image of the chemical construction of Pseudouridine, per https://en.wikipedia.org/wiki/Pseudouridine:

The exact mechanisms and consequences of Pseudouridine are a fairly recent “hot topic” for research, including in the fields of gene therapy and vaccine development. In fact, several COVID-19 “vaccines” have been developed that use Pseudouridine as an ingredient; however, it appeared that this element was lacking in “efficiency” regarding its ability to replace Uridine in the body; and, in fact, Pseudouridine, in this context, created “unintended proteins.” (www.science.org/content/article/mrna-vaccines-may-make-unintended-proteins-there-s-no-evidence-harm. “mRNA vaccines may make unintended proteins, but there’s no evidence of harm”, by Gretchen Vogel. The use of Pseudouridine in the COVID-19 “vaccines” was superseded by the use of the element that is the main topic of today’s post: N1-Methylpseudouridine.

The trail regarding N-1 Methylpseudouridine starts at the presentation in today’s article about Archaea. This element actually has natural sources: https://biology.stackexchange.com/questions/97619/does-n-1-methyl-pseudouridine-occur-naturally-in-any-rna; see the screenshot, below:

Recall that Archaea has various manifestations, including ones that are called Methanogens. Naturally-occurring N1-Methylpseudouridine is found in the soil: one type, Streptomyces lincolnensis (Nebraska origin), forms the basis for the antibiotic lincomycin: www.drugs.com/mtm/lincomycin.html. (Note: this antibiotic is used for severe cases of bacterial infections in persons who are allergic to penicillin.) Lincomycin has a “sister” drug, clindamycin. (https://journals.asm.org/doi/10.1128/aem.02091-18, “TetR-Type Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis“, Yurong Xu, et al., 13 December 2018.)

Below is an image of the chemical construction of N-1 Methylpseudouridine per https://en.wikipedia.org/wiki/N1-Methylpseudouridine:

When ruminating animals (cows, for example) take in N1-Methylpseudouridine from the grass that grows in soil that has Archaea producing this element, it passes through the animal’s body and is released; as solid waste, or as gas (that “cow methane” that the environmentalists are so upset about.) The human body, in its evolved wisdom, “recognizes” that naturally-occurring N1- Methylpseudouridine is not Uridine, and usually will eliminate it. However, this is not the case regarding the type of N1-Methylpseudouridine in the modRNA COVID-19 “vaccines” by Pfizer-BioNTech and by Moderna: In these injectables, the element not only is a “lab-synthesized and enhanced” form; in this form, it is deliberately included in the “vaccines” to replace the natural Uridine in the body of the “vaccinated” person. This Uridine replacement is done for two reasons: One, to “increase” the utilization of the modRNA COVID-19 “vaccines” in the “vaccinated” persons’ body; and, Two, to evade and/or destroy the “vaccinated” person’s body’s natural capability to “recognize” the foreign element and to eliminate it. Yours Truly will repeat this: The natural Uridine RNA of the “vaccinated” person’s body is replaced with the “lab-synthesized and enhanced” version of N-1 Methylpseudouridine in the modRNA COVID-19 “vaccines.”

Please refer back in today’s post regarding the multiple beneficial activities of natural Uridine in the human body. These multiple beneficial activities are either depleted or completely replaced by the “lab-synthesized and enhanced” version of N-1 Methylpseudouridine in the modRNA COVID-19 “vaccines” — in order for the ingredients and mechanisms of these injectables to work in the “vaccinated” person’s body.

Experiments using various “lab-synthesized and enhanced” forms of N1-Methylpseudouridine have been in process for some time. An important paper that describes this type of experimentation is here: https://doi.org/10.1002/stem.2402, “Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges”, Andreas Behring et al., 2 June 2016. Below are three screenshots from this paper, beginning with a portion of the section Protein Synthesis in Cells:

Followed by Table 1 of the above paper, listing the natural immune system responses when “foreign RNA” is detected in the human body (the numbered links lead to various papers):

And, followed by a portion of the section Modifications of the Synthetic mRNAs from the Behring, et al., paper:

Note the mention of “100% replacement” of Uridine.

The type of N1-Methylpseudouridine used in the Pfizer-BioNTech and in the Moderna modRNA COVID-19 “vaccines” is a “lab-synthesized and enhanced and turbo-charged” version. It is called N1-Methylpseudouridine-5′-Triphosphate. Below is the entry from one commercial lab where this version can be purchased (the N-1081 is the catalog number at TriLink Biotech for the compound):

Below is a screenshot of the chemical construction of this version of N1-Methylpseudouridine used in the modRNA COVID-19 “vaccines”, sold by New England Biolabs:

Where was this “lab-synthesized and enhanced and turbo-charged” version of N1-Methylpseudouridine inserted in the modRNA of the SARS-CoV-2 spike protein for use in the modRNA COVID-19 “vaccines”? On both ends of the RBD (Receptor Binding Domain) area of the SARS-CoV-2 virus spike protein (https://pmc.ncbi.nlm.nih.gov/articles/PMC80433204, “Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines”, Kellie D. Nance, Jordan L. Meier, 6 April 2021. This important paper describes the process of how this ingredient truncates the body’s natural immune mechanisms and processes that would normally “recognize” this element as a “foreign RNA” and eliminate it. Below is a screenshot from the paper of the location on the RBD section of the SARS-CoV-2 spike protein where this “foreign RNA” was inserted (the light pink areas mark the beginning and end of the insertion):

And, from the above paper, a screenshot of the entire SARS-CoV-2 virus spike protein code as used by Pfizer-BioNTech for the company’s “flagship” modRNA COVID-19 “vaccine”, BNT162b2. The areas that were used to “insert” the coding sequence changes for the synthesized, enhanced, and “turbo-charged” version of N1-Methylpseudouridine are marked in pink:

The use of forms of N1-Methylpseudouridine is being touted as “the best approach” for inclusion in mRNA products. This is because N1-Methylpseudouridine “does a better job” of replacing the natural Uridine in the “vaccinated” person’s body: https://doi.org/10.1038/s41598-022-17249-1, “N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs”, Jennifer Ong, et al., July 2022. However, there are problems with this situation; among them, the evidence that “frameshifting” is induced: https://doi.org/10.13140/RG.2.2.36710.40005, “Ribosomal frameshifting and misreading of mRNAs in COVID-19 vaccines produce “off-target” proteins and immune responses eliciting safety concerns: Comment on UK study by Mulroney et al.”, David M Wiseman, Jessica Rose, et al., December 2023. The National Cancer Institute defines “ribosomal frameshifting” as follows, below (www.cancer.gov/publication/dictionaries/genetics-dictionary/def/frameshift-mutation):

In other words, a kind of “unintended consequence” from using things like “lab-synthesized and enhanced and turbo-charged” forms of N1-Methylpseudouridine in modRNA COVID-19 “vaccines.” Dr. Peter McCullough’s important take on this issue is here: https://doi.org/10.1002/prp2.1218, “Long-lasting, biochemically modified mRNA, and its frameshifted recombinant spike proteins in human tissues and circulation after COVID-19 vaccination”, Peter A. McCullough, et al., 12 June 2024. Below is a screenshot of a portion of this paper:

In other words, the frameshifting induced in the COVID-19 “vaccinated” person’s body via the use of synthesized, enhanced, and “turbo-charged” N1-Methylpseudouridine in the injectable is pervasive and long-lasting.

To summarize the above: N1-Methylpseudouridine, as it is used in the “synthesized, enhanced, and turbo-charged” form found in the modRNA COVID-19 “vaccines”, replaces the body’s natural Uridine (by 100%) in the “vaccinated” person’s body; it assists in the evasion of the body’s natural immune system by these “vaccines”; it assists in the mechanisms of action of these”vaccines” in the body; and it negates the multiple beneficial effects that natural Uridine provides for the body. It replaces the body’s natural Uridine with a combination of what is basically an element (Pseudouridine) that is, at best, a “by-product” of RNA and can cause cancer, plus a “turbo-charged” methylation of Pseudouridine. Yes, a form of methane. Recall that the modRNA COVID-19 “vaccines” cross the Blood-Brain Barrier and enter the brain of the “vaccinated” person’s body. Recall that the modRNA COVID-19 “vaccines” are spread throughout the “vaccinated” person’s body via the dangerous lipid nanoparticles present in these “vaccines.” The result, in Yours Truly’s opinion, is a recipe for disaster. It is inconceivable that the scientists at Pfizer-BioNTech and at Moderna did not know how Uridine works, and how important it is for the human body. In Yours Truly’s opinion, the replacement of Uridine with the “lab-synthesized, enhanced, and turbo-charged” version of N1-Methylpseudouridine was “acceptable” in order to use the modRNA COVID-19 “vaccines” as a vehicle for human cellular modification and “reprogramming”, in addition to assisting in the mechanisms of these “vaccines.”

To the best of Yours Truly’s knowledge so far, Uridine RNA that has been replaced by the N1-Methylpseudouridine form described in today’s post does not “regenerate” in the “vaccinated” person’s body. It may help to Uridine-rich foods (see above in the post), perhaps along with taking a Uridine supplement (the use of Uridine supplementation, in Yours Truly’s opinion, would need to be discussed with a healthcare professional); and for the COVID-19 “vaccinated” person to at least consider refusing to take any further injections of modRNA COVID-19 “vaccines.”

General Summary: The modRNA COVID-19 “vaccines” manufactured by Pfizer-BioNTech and by Moderna contain a “lab-synthesized, enhanced and turbo-charged” version of an element that occurs in the microorganism domain called Archaea. This Archaean element is called N1-Methylpseudouridine. The version in the modRNA COVID-19 “vaccines” is called N1-Methylpseudouridine-5′-Triphosphate. Once inside the “vaccinated” person’s body, this ingredient replaces an important RNA component in the human body, called Uridine. Uridine has multiple beneficial benefits and mechanisms in the human body. It is found in the RNA of various foods, such as beets, goat’s milk and cheese, walnuts, and in beer. N1-Methylpseudouridine-5′-Triphosphate appears to have no natural benefits for the human body; its use in the modRNA COVID-19 “vaccines” is as a vehicle for human cellular modification and “reprogramming”; and, to assist in the mechanisms of these “vaccines.”

UPDATE, Friday 8 November 2024: At the suggestion of SteveInCO, the following comment from Aubergine is included regarding natural assistance for Uridine production in the body (two screenshots, below). Thank you, Aubergine!

Salads with goat cheese and walnuts can work. So can raw broccoli spread with a mixture of goat cheese, a little pepper, and a little Balsamic vinegar.

Peace, Good Energy, Respect: PAVACA