“We do not believe any group of men adequate enough or wise enough to operate without scrutiny or without criticism. We know that the only way to avoid error is to detect it, that the only way to detect it is to be free to inquire. We know that in secrecy error undetected will flourish and subvert.” –J. Robert Oppenheimer
TL;DR – The spike protein not only contains a special sequence that allows it into the cell nucleus – it also has an ability to bring its own spike mRNA sequence with it. Both features appear to be unique among coronaviruses. The features explain genomic incorporation found for both the virus and the vaccines. The special key and the mRNA shepherding can be considered to be defects in any spike vaccine that has them.
Also, NONE of the “bigs” are talking about this, but it is HUGE, if only people will read the paper.
By sheer luck, I was alerted to this new development ASAP on Twitter.
A follower of mine, who I had followed back, posted on Twitter the link to a paper with this title:
Nuclear translocation of spike mRNA and protein is a novel feature of SARS-CoV-2
I immediately realized what this was about.
It’s about how the SARS-CoV-2 (COVID) virus spike protein and its mRNA get into the cell nucleus – an extremely important point which WSB has been hitting on over and over. It’s very important, because THAT is how “genomic incorporation” happens. And genomic incorporation is what HIV does – what retroviruses do. They “get into” the DNA and leave cookies, so to speak.
Sometimes, they leave enough cookies, that the whole virus comes back out, fully functional, and ready to infect. Sometimes, they only leave enough junk in the DNA to cause some damage. Sometimes, they leave enough to change us – and that is why human DNA is filled with “viral leftovers”.
In principle, mRNA technology should NOT do this. We were TOLD that mRNA technology could not do this. But somebody LIED TO US. And not only that – NOBODY – from Bill Gates on down – ever apologized to us about lying, or even about just “being mistaken”.
We’ll get to that later.
You will recall that there are two papers I love to mention.
One is the “Jaenisch paper”, which describes how the SARS-CoV-2 virus manages to get some of its genetic instructions for the spike protein into the DNA of cells.
The other is the “De Marinis paper”, which describes how the Pfizer vaccine did the same thing to human liver cells in vitro – meaning that in an experiment using cells in culture, the Pfizer vaccine got its mRNA sequences into the DNA genetic material of human liver cells, and it did so in a matter of minutes.
McCullough got in a lot of trouble with Twitter for posting this, even though it was utterly true. Now we know that the government was trying to shut it down. They likely used the technicality of McCullough’s very VALID speculation (stated as speculation and concern), which turned out to be correct, IMSO.
These papers explain ALMOST everything. When I saw the Jaenisch paper, I predicted that we would see the De Marinis paper. MEANING – when I saw that the virus could get mRNA into the DNA, I predicted that the vaccine might get its mRNA into the DNA, too. And yes, I was right. Clearly others thought the same thing, and decided to investigate.
Now, after the De Marinis paper, it seemed very obvious to me that one did not need any kind of special conditions or reverse transcription promoters to get the vaccine mRNA to incorporate.
That bothered me, and I suspected, at the time, that MAYBE – just maybe – the spike protein ITSELF was somehow causing genomic incorporation – that it functioned as a kind of reverse transcription promoter.
Well, it sure looks like that is the case.
According to the discoveries revealed in the new paper, which I have taken to calling the “Mehedi paper”, there is a special sequence in the spike protein that acts like a “key to the nucleus” – and this sequence is found in NO other coronavirus spike protein.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe pathophysiology in vulnerable older populations and appears to be highly pathogenic and more transmissible than other coronaviruses. The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2. Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV,” which is absent from the S protein of other coronaviruses. Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. S mRNAs also translocate into the nucleus. S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA. While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel feature of SARS-CoV-2.
Let me put that in plainer English.
COVID-19 really hurts old people and seems to be both deadlier and easier to catch than other coronaviruses. The spike protein seems to be why. Although the spike protein is a surface protein that normally would not do this, it might be predicted to get into the cell nucleus because it has a special sequence “PRRARSV,” a known key to the nucleus which appears in no other coronavirus. Sure enough, the COVID spike protein gets into the nucleus of infected cells. What’s more, the mRNA for COVID spike protein also gets into the nucleus. What happens is that the spike mRNA collects near the spike protein, which helps it get in. While a different protein called the “nucleoprotein” of many coronaviruses is known to get into the nucleus of cells, the penetration of the cell nucleus by BOTH the spike protein AND the mRNA for it, seems to be a unique new feature of the SARS-CoV-2 virus.
Once you read it in plain English, it’s much more mind-blowing.
Now – I really recommend that you read the rest of the paper, but it’s really just technical details about what was mentioned in the abstract. Those details can help you gauge the expectedness or unexpectedness of things, but I have tried to do that as best as I could in the translation.
At this point, you should have all kinds of questions.
could this defect of the vaccines have been predicted?
should it have been predicted?
did the Chinese know this when they sent us the sequence?
did we know it when we got the sequence?
would NOT using the full spike protein have prevented this?
if so, why did we use the full spike protein anyway?
would the “forbidden” Winfried Stöcker RBD vaccine have avoided this?
if so, why was his vaccine suppressed by the German government?
does this affect the Peter Hotez vaccine, Corbevax?
if not, why didn’t his vaccine get promoted through the process quicker?
is nuclear penetration a common problem with mRNA technology?
how did this “key” get into the sequence? Naturally or not?
could “directed evolution” of the spike have yielded this?
why wasn’t this clear from the moment we got the sequence?
did people know this and hide the information?
were key people like Bill Gates (their side) and Robert Malone (our side) aware of this possibility?
The last question is a gift to WSB and her virologist friend. I am by default a defender of Dr. Malone, but WSB and her friend are long-time skeptics of the technology, and thus of Dr. Malone. In all fairness, I think we have to ask EVERYBODY the same questions.
Did people KNOW that mRNA technology had this vulnerability?
Does this look any more like an engineered bioweapon, designed to get into the nucleus?
Was this thing made by nature, by people, or by somebody with more advanced technology?
What is the purpose of getting into the nucleus, if it is designed to do that?
That should be enough. I will leave some links to prior comments I have made, in an appendix, hopefully added later.
Thank you.
W
John Fink and James Coburn discuss case in a scene from the film ‘The Carey Treatment’, 1972. (Photo by Metro-Goldwyn-Mayer/Getty Images)
Get your rest, Trumpy Bear! You’re needed in WASHINGTON, DC!!!
Vladdy Bear and Winnie The Pooh are making Sleepy Creepy Joe look like a punching bag!
The Business At Hand
This Stormwatch Monday Open Thread remains open – VERY OPEN – a place for everybody to post whatever they feel they would like to tell the White Hats, and the rest of the MAGA/KAG/KMAG world (with KMAG being a bit of both).
And indeed, it’s Monday…again.
But we’re ON A ROLL.
The Rules
Boilerplate, more or less, but worth reading again and again, if only for the minor changes, and to stay out of moderation.
The bottom line is Free Speech. Theories and ideas you don’t agree with must be WELCOME here, and you must be part of that welcoming. But you do NOT need to be part of any agreement.
Gonna be quick this time.
SO….. [ENGAGE BOILERPLATE…..]
We must endeavor to persevere to love our frenemies – even here.
Those who cannot deal with this easy requirement will be forced to jump the hoops of moderation, so that specific comments impugning other posters and violating the minimal rules can be sorted out and tossed in the trash.
In Wheatie’s words, “We’re on the same side here so let’s not engage in friendly fire.”
That includes the life skill of just ignoring certain other posters.
We do have a site – The U Tree – where civility is not a requirement. Interestingly, people don’t really go there much. Nevertheless, if you find yourself in an “argument” that can’t really stay civil, please feel free to “take it to the U Tree”. The U Tree is also a good place to report any technical difficulties, if you’re unable to report them here. Please post your comment there on one of Wolf’s posts, or in reply to one of Wolf’s comments, to make sure he sees it (though it may take a few hours).
We also have a backup site, called The Q Tree as well, which is really The Q Tree 579486807. You might call it “Second Tree”. The URL for that site is https://theqtree579486807.wordpress.com/. If this site (theqtree.com) ever goes down, please reassemble at the Second Tree.
If the Second Tree goes down, please go to The U Tree, or to our Gab Group, which is located at https://gab.com/groups/4178.
We also have some “old rules” and important guidelines, outlined here, in a very early post, on our first New Year’s Day, in 2019. The main point is not to make violent threats against people, which then have to be taken seriously by law enforcement, and which can be used as a PRETEXT by enemies of this site.
In the words of Wheatie, “Let’s not give the odious Internet Censors a reason to shut down this precious haven that Wolf has created for us.”
A Moment of Prayer
Our policy on extreme religious freedom on this site is discussed HERE. Please feel free to pray and praise God anytime and anywhere.
Thus, please pray for our real President, the one who actually won the election.
After his speech at CPAC, I think it’s quite clear that praying for President Trump’s return to the White House is indeed praying for our enemies, who are too messed up to realize how much better off they would be under a Trump presidency.
MUSICAL INTERLUDE
For your listening enjoyment, and general encouragement, we continue Wheatie’s tradition of fine music videos, shipped fresh from the seas of information by our intrepid authors.
Microwave Monday reminds me of this song from back in the day.
ENJOY!
This right here is the stiffest dose of teased-out 80s chick hair you are EVER going to get.
And if you want to see it with 2008 hair….
And then there’s an outdoorsy 2014 version which has a really great “live” feel…..
But how about a 2021 version with just Susanna Hoffs and a string section?
But if you’re still feeling like it’s all unfamiliar, here’s the original video!
Yeah – that’s more like it!
Call To Battle (H/T Sundance)
Our beloved country is under Occupation by hostile forces.
Daily outrage and epic phuckery abound.
We can give in to despair…or we can be defiant and fight back in any way that we can.
Joe Biden didn’t win.
And we will keep saying Joe Biden didn’t win until we get His Fraudulency out of our White House.
…..and now for…..
Microwave Monday
After recent discussion of Havana Syndrome, and the possibility that it involves electromagnetic radiation (and in particular microwaves), I have decided that we all need to LEVEL UP our gut-level understanding of the electromagnetic spectrum – even beyond what Steve has done with his explanation of the science behind it.
This will also help us deal with both the REALITIES and DISINFORMATION of 5G telecom.
I will be doing this by giving you all a bunch of INFOGRAPHICS to get started.
Steve got us started HERE, in his 8th science lesson on LIGHT.
You may remember some of this stuff….. (CLICK TO ENLARGE)
Let’s start breaking up that electromagnetic continuum into REGIONS that have NAMES.
You can see that microwaves lie between RADIO and INFRARED.
Let’s look even more closely at those groups.
We can even start breaking those radio and microwave regions down into BANDS that you are all familiar with.
Here you can start to get a feel for the SIZE OF THE WAVES versus objects and frequencies.
The SIZE OF WAVES and WHAT THEY AFFECT actually matters – although it’s not simple.
Megahertz, gigahertz, teraherz, and petahertz are all there.
You can really see it more easily in the following infographic.
You can easily see how we have made “radio devices” push farther and farther away from the very SAFE “radio” region, through television, mobile phones, and WiFi, closer and closer to the microwave and infrared radiation that constitutes COOKING MICROWAVES and RADIANT HEAT ITSELF.
And as you can see here, many technologies emit electromagnetic radiation – and some more than you may have realized.
So where are the 5G frequencies? Please be aware that there is constant change in this stuff, so that these infographics may be slightly out of date. Do not let that deter you – minor changes don’t NIX any issues of the basic range in which 5G operates, unless specifics of the science are given.
Use COMMON SENSE.
Let’s zoom in a bit.
Note that the above is just the US – other countries use different regions.
Here is more detail on European and US 5G.
Much of this is SQUARELY in the microwave region. From Wikipedia, we’re basically talking 300 MHz to 300 GHz.
Now let’s start looking at ALLEGED but possibly REAL health effects of EMR in the microwave region, which may VARY ACROSS THE REGION.
Remember also that DOSAGE MATTERS – like anything else.
You have to squint to see the next infographic, but look at “Biological Effect”.
It depends strongly on FREQUENCY / WAVELENGTH.
This is a very good listen. This lady is also a climate dupe, but she will get you to realize that your microwave devices may actually be doing to YOUR MEAT what microwaves normally do to YOUR MEAT, albeit at LOWER BUT LONGER DOSAGES.
This is another good one!
More of her schtick. This gal will get you to question the “harmless” narrative, just like vaccines, but try to keep some common sense. Remember – driving is a killer, too. You still want the freedom to drive?
Common sense! How do we get the BEST of both worlds?
Now I’m just going to play a bunch of their infographics. Caveat emptor! But some of this stuff is interesting and counter-intuitive. SIGNAL and NOISE matter. In more ways than one.
SO – maybe you should THINK about how to handle the devices you have!!!
But then talk back to all that stuff HERE.
Be sure to be SKEPTICAL of this SKEPTIC lady – that is an essential part of ETHICAL SKEPTICISM. We don’t want to be panicky about 5G, or believing disinformation, but we do want to treat MICROWAVES as maybe not that awesome for our health, in doses that exceed our individual sensitivity.
So BEWARE of BROAD-BRUSH SKEPTICS who downplay too much in favor of technology.
After all, we just got through a BATTLE ROYALE over disastrous mRNA technology that was advanced too fast for all the wrong reasons.
Finally, a GREAT infographic. It’s MASSIVE. I’m only showing you the small version – you have to click the link for the BIG ONE that’s easy to read down to the details.
Something stinks, and to my nose, it’s the New World Odor.
But first, a disclaimer.
I’m actually ashamed that I wanted to work for Google at one point, but I need to get that out into the open right away, lest somebody, someday, use that “gotcha” against me and think it’s actually damaging.
Heck – I even bought a variety of Google swag, back when they were small and upstarty, just like when Netscape, Firefox, various Linux brands, and other rising tech companies were once “new” and “cool”.
A lot of people once thought that Google’s motto of “Don’t be evil” was a bit of a bass-ackwards under-performer, which should have been a positive, rather than a double-negative. Not me. I realized back then that this paradoxical formulation was exactly why the motto was so ahead of the curve.
“Being good” lacks skepticism – particularly of self. “Being good” as a primary motivator is a guaranteed set-up for the primary sin of PRIDE.
“Not being evil”, in contrast, is automagically skeptical of self. And skepticism isn’t just good for science – it’s good for religion.
Yes – I think it’s clear you need both. This is part of why (IMO) Christianity always refreshes itself by going back to its Jewish roots when there are foundational questions. No matter how you slice it, we need to concern ourselves with the Law, which includes consequential negatives, because we don’t want to get rid of our saving prohibitions.
We need our Peters, but we also need our Pauls.
Thus, when Google ditched “don’t be evil”, I smelled trouble.
And what is happening now, may be evidence that Google has forgotten how to “not be evil”.
Google has made mistake after mistake since they began tampering politically with their search engine, largely during the Obama years, but to an even greater degree during the Trump years. And now, in one short year of Biden – Google has arrived at the point of adopting a policy that conflicts with the most basic principles of science.
Simone Gold, of America’s Frontline Doctors, just tweeted this.
WOW: @Google sent notice stating they will be removing the America’s Frontline Doctors website from search results.
We are a team of medical doctors who dared to speak the truth.
“Nor do we allow content from any site that contradicts or runs contrary to scientific or medical consensus and evidence-based best practices.”
Well THAT’S great. How do you think science is going to advance? YOU CHUMPS!
Let’s just save that tweet, simply to make sure that it doesn’t disappear when Twitter inevitably suspends Dr. Gold.
Note these final words from Dr. Gold.
“And we have been proven right, again and again, and again.“
Dr. Simone Gold, AFLD
Dr. Gold is not lying. Throughout COVID-19, free and independent doctors and scientists have been LEADING captive science and captive medicine against their BIASED FUNDERS AND CONTROLLERS – which clearly include GOOGLE now.
The “concensus” science has repeatedly and continuously been ABNORMALLY WRONG due to BIAS, and has required continuous correction by – very sadly – OUTSIDERS.
Science does not progress by sticking to consensus. It advances by CHALLENGE TO CONSENSUS. Google is INTERFERING with that process. SHAME!!!
In my opinion, “they” are all scared.
And the reason they’re scared it this.
Now – as insurance companies look around to see who picks up the tab for people dying from the ERRORS OF THE CONSENSUS, it sure ain’t gonna be able to pin it on the people who WARNED about the experimental vaccines.
It may indeed be that some of the blame (moral, even if not monetary) will land on those who CENSORED THE SAVING WARNINGS.
Over and over, people like Google censored us because they said that the things WE SAID were not true, and yet it turned out that the things we said WERE true, and that the consensus THEY said was true, was both WRONG and responsible for MANY DEATHS.
And THIS may be the biggest CENSORED TRUTH of all.
Alden et al, Lund University, Sweden, confirms one of our worst fears. The exogenous genetic material coding for the dangerous Spike protein is reverse-transcribed into the human genome; possible long-term constitutive expression/synthesis of disease promoting/lethal Spike. pic.twitter.com/JEzSwSruWM— Peter McCullough, MD MPH (@P_McCulloughMD) February 25, 2022
Here, I saved an image of a copy which was only partially destroyed by Twitter.
And here I saved the actual tweet (in two pieces).
Here is that image within the tweet, in more detail.
So what is McCullough talking about? And what is Twitter hiding?
Academic Editor: Stephen Malnick Curr. Issues Mol. Biol. 2022, 44(3), 1115-1126; https://doi.org/10.3390/cimb44030073 (registering DOI) Received: 18 January 2022 / Revised: 19 February 2022 / Accepted: 23 February 2022 / Published: 25 February 2022 (This article belongs to the Topic Clinical, Translational and Basic Research on Liver Diseases)
Abstract
Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure.
I have discussed the Jaenisch paper numerous times since I became aware of it in December of 2020, and more importantly in March of 2021.
In fact, in the following blog post I made in April of 2021, I actually hypothesized a scenario which is basically the findings of the De Marinis paper!!!
Alternate Title: Is Persistent Reverse Transcription a Hidden Virus/Vaccine Objective? Gloating Pre-Preface There are few feelings of satisfaction like opening up the NEWS and knowing one’s theories and understandings are WORKING even better than one thought. Let’s see if they use this one for damage control, and get the “new science” out before the STORY …
Now – let me state, in the simplest possible way, what these papers mean.
The Jaenish paper proves that the SARS-CoV-2 (COVID-19) virus alters human DNA.
The De Marinis paper proves that the Pfizer mRNA vaccine also alters human DNA.
Oh, there are quibbles that I’m “oversimplifying”, but they’re just quibbles, and I will show you WHY they are not just quibbles, but extremely disingenuous ones.
And please note that I am UNDERSTATING when I just say “alters DNA”. The Jaenish paper proves that the viral DNA changes are going into GENOMIC DNA. The De Marinis paper strongly suggests that THE SAME may be happening due to the vaccine.
But before I give you MY take on the De Marinis paper, let me give you the opinions of OTHERS.
Let’s review one first.
Peter McCullough:
Alden et al, Lund University, Sweden, confirms one of our worst fears. The exogenous genetic material coding for the dangerous Spike protein is reverse-transcribed into the human genome; possible long-term constitutive expression/synthesis of disease promoting/lethal Spike.
Translation: The pseudo-mRNA code for the spike protein in the Pfizer vaccine gets into the genomic DNA inside human cells in test tube experiments, and produces both DNA and mRNA coding for what was uniquely in the vaccine. This new cellular DNA and RNA very likely (as a consequence) produces spike protein, causing long-term disease and health issues.
One can legitimately contest the assertion that genomic DNA is being altered (we don’t know this yet – hopefully soon), but any denial of the fact that CELLULAR DNA is being changed, is simply not “fact-based”.
For example, I saw “downplay trolls” on the original McCullough tweet, quibbling about in vivo vs. in vitro – that these results don’t “prove” that the same thing happens in living humans – only in living human cells in a test tube.
The reason this is a hypocritical crock of shit, is that “due to an abundance of caution”, almost every single “carcinogen” and other “bad boy chemical” that is restricted or controlled in the United States, at the cost of trillions of dollars which go into the pockets of the deep state and China, is because of IN VITRO results.
Thus, if it’s OK to have vaccines that do what Pfizer’s vaccine does, then it’s OK to remove the restrictions on benzene, and have benzene everywhere. Likewise for thousands of other chemicals.
Starting to see how this works? Let’s move on.
Alex Berenson:
Hey, remember how they told you the mRNA in the vaccines could NEVER wind up in human DNA? A new study out of Sweden suggests otherwise (at least in lab-grown cells).
Don’t worry, everything is fine.
After all, we have all that long-term placebo-controlled clinical trial data proving the safety of these mRNA shots.*
So About Not Needing Actual Study…[Comments enabled]
Oh, mRNA won’t get taken up into cell lines and thus can’t propagate on a permanent basis in the human body, we were told.
Indeed that’s rather important. Mutagenic (cancer), cytotoxic (you’re ****ed) and teratogenic (any child you give birth to or sire is ****ed) things that get into cellular DNA can lead to irreversible damage because most cells in the body are replaced on regular basis.
There’s an infamous quote that is in fact wrong: Our body fully replaces itself every seven years. That’s not true. It came out of a study that looked at the average age of cells in a human, using Carbon-14 dating. Anyone who has done any sort of statistical work knows the problem with averages: They are just that, and the statistical outliers are there but unaccounted for with such simplistic tripe.
There are several types of cells that are never replaced. Certain ones in the cerebellum, for example, that deal with coordination and balance, those in the ocular lenses and the eggs in a woman’s ovaries.
There are also cells that are much more-frequently replaced. Red blood cells, for example, have a roughly 90 day life cycle. This is why an A1c test, which measures glycated hemoglobin (that is, red cells that have been damaged by glucose) will tell you what your average blood glucose level has been over the last three months. The epithelial cells in your intestines last only about five days, and the live (dermal) part of your skin is replaced in about 2 weeks. Skeletal muscle and the rest of your intestines, on the other hand, are good for around 15 years.
But with few exceptions it is indeed true that most cells are in fact replaced. This is why you can get cancer; when there is an error in that replication the result can be a cell that has wildly damaged regulatory mechanisms on self-replication. If that damage kills the cell immediately then there’s no real foul, but if it leads to much more rapid reproduction…… that’s cancer.
We have known for quite a while that viruses can and do in some cases infiltrate into DNA. We know this because we’ve found pieces of viral RNA in our genome and not a few of them either; they’re literally all over the human genomic code. It’s wildly improbable that said congruence happened by random alignment of the various codons in our genetic code; ergo, it got in there at some point in evolution and then got into either the eggs of a developing female fetus or the sperm of a male and thus propagated. We only know, of course, about the integrations that weren’t fatal to offspring or the person in question. We also know that in general genetic mutation is harmful or fatal nearly all the time, so that we have said evidence in our genome means this sort of thing happens quite frequently and most of the time it screws the person who has it happen to them.
Indeed some cancers are blamed on viral infections where the viral RNA gets transcribed into the DNA of the cells and causes said errors.
mRNA is not really “new” technology; Moderna has been trying to make it work for cancer, for example, for a long time — without success. The reason for failure has always been dose-related toxicity that has overtaken the benefit when used in sufficient quantity to actually deliver a therapeutic effect. This is not an uncommon reason for drug and therapy failure; in fact that too happens all the time.
But we didn’t bother doing intermediate and longer-term study on the specifics of using mRNA (or, for that matter, a modified virus as with J&J) to deliver a partial viral payload in this regard before rolling it out. Instead, we just trusted that there’d be no integration. Indeed zero epigenic, mutagenic and teratogenic studies were done;they take years to do and we just flat-out didn’t bother. Where we had original control groups in the summer and fall of 2020 we intentionally destroyed them by giving the placebo arm of the original trials the drug three months later, making analysis on any sort of clean analytical basis impossible.
This was wild arrogance given that we know viruses do indeed integrate via infection. To presume it won’t happen here, when we cause cells to produce viral proteins, when the very same thing, producing viruses when a cell is infected, sometimes does is ridiculously and wildly-irresponsible arrogance.
In the BNT162b2 toxicity report, no genotoxicity nor carcinogenicity studies have been provided [26]. Our study shows that BNT162b2 can be reverse transcribed to DNA in liver cell line Huh7, and this may give rise to the concern if BNT162b2-derived DNA may be integrated into the host genome and affect the integrity of genomic DNA, which may potentially mediate genotoxic side effects. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome.
This study does not prove that said genetic pollution has occurred, but it raises the distinct possibility as the precursor events required for this to occur are now known to happen with scientific certainty.
We don’t know because we deliberately did not look; the studies were not done prior to use.
Genomic deoxyribonucleic acid (abbreviated as gDNA[1]) is chromosomal DNA, in contrast to extra-chromosomal DNAs like plasmids. Most organisms have the same genomic DNA in every cell; however, only certain genes are active in each cell to allow for cell function and differentiation within the body.[2]
The genome of an organism (encoded by the genomic DNA) is the (biological) information of heredity which is passed from one generation of organism to the next. That genome is transcribed to produce various RNAs, which are necessary for the function of the organism. Precursor mRNA (pre-mRNA) is transcribed by RNA polymerase II in the nucleus. pre-mRNA is then processed by splicing to remove introns, leaving the exons in the mature messenger RNA (mRNA). Additional processing includes the addition of a 5′ cap and a poly(A) tail to the pre-mRNA. The mature mRNA may then be transported to the cytosol and translated by the ribosome into a protein. Other types of RNA include ribosomal RNA (rRNA) and transfer RNA (tRNA). These types are transcribed by RNA polymerase II and RNA polymerase III, respectively, and are essential for protein synthesis. However 5s rRNA is the only rRNA which is transcribed by RNA Polymerase III.[3]
Used in a sentence:
While we tend to be more concerned about changes to genomic DNA, changes to any kind of human DNA are potentially problematic.
